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Posted June 17, 2020
Flow Cytometry Specialist-Hematological Malignancies Program
New York, NY
Location: Upper East Side
Org Unit: Melnick Lab Manager
Exemption Status: Exempt
This role supports flow cytometry-based basic and translational research for the Heme Malignancy Program. The primary responsibilities include operation of florescence activated cell sorting (FACS) and analyzer instruments, maintenance of flow cytometry equipment, quality control procedures, sample and process tracking, working closely with research scientists and assisting in the training of new users. This role independently performs a full range of complex assignments and projects that involve intensive application of knowledge of flow cytometry in the fields of immunology and cancer biology.
Calibrates, maintains and conducts quality control procedures of major fluidic and Optical systems of the flow cytometer, including scheduling, troubleshooting maintenance of one 5-laser Aria BSL2 sorter and Cytek Aurora analyzer.
Responsible for daily instrument calibration, modifications and adjustment of instrument parameters; identifies control samples, according to experimental requirements.
Ensures protocols are clearly understood and sorting is carried out exactly as requested. Maintains close communication with principal investigators during sorting phase of experiments and contacts researchers with any questions or issues.
Maintains reagents and supply inventory.
Records quality assessment metrics for flow cytometry results. Reports and documents deviations from standard operating protocols.
Schedules use of cell sorting and analyzer equipment to ensure maximum availability.
Responsible for establishing and maintaining record keeping systems of instrument parameters, computer data backups and instrument usage.
Reviews current flow cytometry literature for improved methodologies and quality control procedures.
Provides additional technical support and troubleshoots instrument or computer problems as they arise.
A minimum of 2 years experience with experimental design and experimental execution with multi-color flow cytometric technology.
Flow Cytometry Analyzer experience is required (ie 4-5 laser Fortessa or LSR equivalent).
Experience in the operation of multiparameter cell sorters is highly desirable, but not required. Sorter training will be provided.
Knowledge of BD DIVA software and hardware is required.
Knowledge of biology and scientific approach in order to perform the full range of duties related to experimental protocol and the use of the cytometer to design experiments for original research.
Technical knowledge of aerosol containment and biosafety control procedures associated with flow sorting is preferred.
Experience writing laboratory SOPs and technical instructions is preferred.
Skilled in developing new applications for the cell sorter and participation in the design of experiments.
Knowledge, Skills and Abilities
Excellent written and verbal communications skills, experience communicating with peers and management of a scientific nature.
Highly organized and self motivated.
Weill Cornell Medicine is a comprehensive academic medical center that's committed to excellence in patient care, scientific discovery, and the education of future physicians in New York City and around the world. Our doctors and scientists-faculty from Weill Cornell Medical College, Weill Cornell Graduate School of Medical Sciences, and the Weill Cornell Physician Organization-are engaged in world-class clinical care and cutting-edge research that connect patients to the latest treatment innovations and prevention strategies. Located in the heart of the Upper East Side's scientific corridor, Weill Cornell Medicine's powerful network of collaborators extends to its parent university Cornell University; to Qatar, where an international campus offers a U.S. medical degree; and to programs in Tanzania, Haiti, Brazil, Austria and Turkey. Our medical practices serve communities throughout New York City, and our faculty provide comprehensive care at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, NewYork-Presbyterian/Lower Manhattan Hospital, and NewYork-Presbyterian/Queens. At Weill Cornell Medicine, we work together to treat each individual, not just their conditions or illnesses, as we strive to deliver the finest possible care for our patients - the center of everything we do. Weill Cornell Medicine is an Equal Employment Opportunity Employer. Weill Cornell Medicine provides equal employment opportunities to all qualified applicants without regard to race, sex, sexual orientation, gender identity, national origin, color, age, religion, protected veteran or disability status, or genetic information.
Posted May 17, 2020
Lab Supervisor-Flow Cytometry
Are you an experienced medical laboratory professional interested in advancing your career in a fast-paced and exciting clinical research laboratory? Q² Solutions is seeking a certified medical technologist/Lab Supervisor with a proven track record of delivering high quality laboratory results, able to supervise a small team of flow cytometrists. Responsibilities will include planning, assigning and directing work, appraising performance and guiding professional development of technologists, leading implementation of new tests and technologies, enhancing laboratory procedures and contributing to continuous improvement initiatives to increase quality of services and operational efficiency.
Supervise the evening shift team of laboratory staff. Assist with administration of laboratory testing in accordance with applicable regulations governing clinical laboratories.
Supervise the daily activities of assigned laboratory work group(s) through appropriate delegation, technical skills training, and work supervision. Meet regularly with staff and senior management to discuss and resolve workload and technical issues.
Screen and assign workload. Plan, prioritize and assign tasks and projects. Counsel, train and coach laboratory staff.
Monitor work, develop staff skills and evaluate performance.
Assist in establishment and revision of laboratory policies and procedures. Maintain appropriate control and quality assurance procedures. Ensure compliance with safety requirements.
Keep abreast of new technical developments. Assist with implementation of new tests, equipment, programs and/or procedures in the assigned area(s) as needed. Contribute to continuous improvement initiatives to increase quality of services and operational efficiency.
Foster a unified culture and facilitate collaboration, corporation, sharing of information and teamwork.
Participate in initiatives to improve employee engagement to positively impact operational results, customer satisfaction and employee retention.
Manage staff in accordance with organization’s policies and applicable regulations. Responsibilities include planning, assigning, and directing work; appraising performance and guiding professional development; rewarding and disciplining employees; addressing employee relations issues and resolving problems. Approve actions on human resources matters.
REQUIRED KNOWLEDGE, SKILLS AND ABILITIES
Knowledge of in clinical testing procedures (flow cytometry).
Knowledge of laboratory testing regulations (GLP, GCP or CLIA).
Working knowledge of quality assurance and quality control principles
Knowledge of occupational safety and health rules and regulations
Good written and oral communication skills
Effective supervisory and coaching skills
High ethical standards
Ability to assess and prioritize and deliver multiple tasks, projects and demands
Ability to establish and maintain effective working relationships with coworkers, managers and clients.
MINIMUM REQUIRED EDUCATION AND EXPERIENCE
Bachelor's degree in a health sciences field with 4 years laboratory experience and certification; Master’s degree with 3 years of laboratory experience and certification; PhD with 2 years laboratory experience
Minimum 2 years flow cytometry experience
Minimum 2 years supervisory experience; or equivalent combination of education, training and experience.
ASCP, AMT, NCA certification in Medical Technology (MT) or Medical Lab Scientist (MLS) preferred. AAB certification is also acceptable
Extensive use of telephone and face-to-face communication requiring accurate perception of speech
Extensive use of keyboard requiring repetitive motion of fingers
Regular sitting for extended periods of time
Work is performed in a laboratory environment, full manual dexterity and visual acuity required
May be exposed to potential physical harm from hazardous chemicals, infectious diseases, blood-borne pathogens, toxic materials, toxic gases, electrical hazards, dangerous tools and equipment
Posted May 17, 2020
Flow Cytometry Lab Manager
Ideal candidate will be an experience Lab manager with a Flow Cytometry background
Must have ASCP, AMT, NCA certification in Medical Technology or a PhD or MD qualified
Maintain department directory of service and associated global test codes. Support regional cost sheets and price sheets.
Maintain strong internal and external relationships, including global site heads.
Management, oversight and coordination of the transition of clinical trials tests from development into global operations.
Ensure reliable, secure global procedures are developed, maintained and documented for new tests being implemented.
Support Scientific Affairs and Sales in the acquisition of new testing.
Review and approve quality control reports used to assess the validity of testing procedure, initiate remedial/corrective action where indicated.
Review existing department procedures and make appropriate recommendations to global Lab Operations Managers.
Assist Scientific Affairs regarding technical requests including technical principles, advice on choice of tests, test development, cost of testing and result interpretation.
Provide clear and timely communication lines with Test Development, Scientific Affairs, Project Management, Pharmaceutical sponsors, laboratory operations, and investigators to ensure global services are developed and appropriate with all regulatory and customer requirements.
Develop a good understanding of the Q2 Solutions business and build relationships with global scientists and global laboratory operations.
Provide oversight to ensure reliable secure global technical and operational procedures are in place and provide support for improvement opportunities globally.
Remain aware of scientific and other advances, as the subject matter expert for department development and maintain skills and knowledge appropriate to the post by undertaking training and attending meetings and conferences.
Ensure that safety, environmental, company and departmental policies and procedures are disseminated, understood, complied with and documented.
Ensure that employees receive appropriate training in working practices in line with local regulatory bodies.
Be familiar with the safety, environmental rules and procedures applying to the job and take reasonable care for personal safety and that of other people.
Understand and apply the site Safety, Environmental Policy, Safety Management System and relevant legal safety & environmental requirements
Knowledge, Skills and Abilities
Excellent communication (interpersonal, verbal and written) skills, ability to communicate effectively at all levels.
Knowledge of PC applications
In depth knowledge of in clinical testing procedures (flow cytometry).
In depth knowledge of laboratory testing regulations (GLP, GCP or CLIA).
Working knowledge of quality assurance and quality control principles.
Ability to work with global teams.
Ability to establish and maintain effective working relationships with coworkers, managers and clients.
Knowledge of Health/Safety and Environment good practice.
Duty to comply with all applicable standards as required by the company.
Deep scientific knowledge/experience with the ability to troubleshoot, guide and provide direction/performance management of staff as well have an understanding of operating budget and impacts to overall P&L.
Skilled in extracting data to measure KPI's and drive continuous improvement
Strong knowledge of relevant procedures, processes, and regulations; Working knowledge of department systems (i.e. QLIMS, NewLIMS, QNET, LabMatrix).
Strong knowledge of lab safety; proficient in Microsoft Office
Good written and oral communication skills
Strong supervisory and coaching skills
High ethical standards
Ability to assess and prioritize multiple tasks, projects and demands
Posted May 5, 2020
Principal Scientist Global Product Quality
Can also be based in Seattle WA
Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.
Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.
The Cellular Therapies Development and Operations (CTDO) organization is seeking a Principal Scientist who will be responsible for the quality oversight of Flow Cytometry methods in support of the Cellular Therapy product portfolio. This position will report into the Global Product Quality group. Successful candidates will have a strong foundation in multi-parameter flow cytometry assays and demonstrated experience working in a cGMP environment.
Responsible for the stewardship of late-phase flow cytometry methods in the Quality organization.
Implement method lifecycle and method maintenance programs to support flow cytometry methods used in the release of cell therapy drug products.
Responsible for transfer and validation of methods from Development to Quality Control (QC) laboratories in compliance with global regulatory requirements.
Responsible for authoring relevant analytical sections of submissions, responding to health authority questions and representing the QC function during inspections.
Function as the flow cytometry technical expert for QC labs during internal QC investigations and as the Quality liaison with contract test labs during QC investigations.
Partner with development organizations in the design of development and qualification studies, selection and characterization of reagents, and method optimization initiatives. Represent the QC department on cross-functional project development teams.
Qualifications and Education Requirements
BS/MS in a scientific discipline and 10+ years of experience in multi-parameter (>10-color) flow cytometry execution, training, and technical support. Experience in cellular therapies is preferred.
Strong scientific background and expertise with multiple flow cytometry platforms from analyzers to cell sorters.
Experience in analytical method lifecycle, including method transfer, validation and maintenance. Experience providing training in method execution as well as instrument operation and standardization. Experience with implementing flow cytometry methods in a commercial QC facility is preferred.
Experience in cGMP regulations and application within the Quality Control environment. Understanding of FDA, EMA, ICH, USP, and EP guidelines and regulations associated with the quality control of biological products.
Must possess effective time management skills, demonstrate initiative, resourcefulness and flexibility to work independently and as part of a team.
Strong technical writing experience (SOPs, Method Validation Protocols and Reports) is required.
Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.
Posted March 14, 2020
Senior Associate Scientist, Oncology Discovery – Immuno-Oncology
Janssen Research & Development, L.L.C
Spring House, Pennsylvania
Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Senior Associate Scientist, Oncology Discovery – Immuno-Oncology, located in Spring House, PA.
At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science.
We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.
As a Senior Associate Scientist within Immuno-Oncology, Oncology Discovery responsibilities will include:
• Support Oncology discovery and Translational research by providing flow cytometry expertise.
• Perform daily instrument set-up of up to 20 BD Diva based flow cytometers and 4 BD cell sorters. Monitor all calibration results to ensure optimal performance and maintain appropriate instrument configurations
• Perform all preventative maintenance activities for instruments and computers, including scheduling and maintenance of service contracts, database back-up, quarterly data transfer/sample disposal, collaboration with IT for computer upgrades and maintaining network access and data share accessibility.
• Aid users in troubleshooting to minimize instrument downtime and need for service calls. Resolve common issues as appropriate, communicate any ongoing issues to users and update calendars as required.
• Perform cell sorting services by request for all non-trained employees. Provide instrument set-up and additional troubleshooting for all trained employees.
• Train all new users on flow core rules and regulations
• Stock all fluids, parts, consumables, and frequently used reagents
• Establish and manage user calendars for each instrument.
• Support all groups as needed with advanced assay/panel design, compensation set-up or issues, and flow data analysis using FlowJo and Cytobank
• Maintain detailed and organized experimental records and stay compliant on all relevant internal and external training requirements
• Process tissue (blood, lymph nodes, tumor, prostate, lung, muscle, spleen, and thymus) to single cell suspension for analysis of immune, tumor, and/or stromal cells by Flow cytometry or other biological methods to support IO efforts
• Stain and characterize both primary immune cell populations and cell lines by multiparameter (8-16 colors) flow cytometry
• Remain up-to-date on the latest flow cytometry trends, assays, and reagents to share across the department.
• Recommend additional training/host relevant speakers to individuals or department as needed.
• Develop and present summaries of data and recommendations
• A minimum of a BS Degree with a minimum of four years’ experience or an MS with two years’ working with flow cytometers in industry or an academic setting is required
• Experience with multi-color flow cytometry including compensation is required
• Experience with troubleshooting BD flow cytometer instrument and software issues is required.
• Experience with FACS (cell sorting) is preferred. Ability to travel to attend specific trainings as needed.
• Experience in design and interpretation of cell-based assays/experiments to interrogate questions in Immunology and oncology is preferred
• Experience with receptor density determination is preferred
• Experience with aseptic technique, cell culture and basic immunogenicity assays is preferred
• Experience with in vivo models of tumor biology, tissue processing, and subsequent flow cytometry is preferred
• Excellent communication/collaboration skills are essential including; interfacing with group leaders, lab managers, and upper management to ensure that instruments are in working order and project priorities are being met is required
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
United States-Pennsylvania-Spring House-
Janssen Research & Development, LLC (6084)
Posted March 11, 2020
Human Immune Monitoring Core (HIMC) at Columbia University
New York City
The Human Immune Monitoring Core (HIMC) at Columbia University in the New York City is seeking two (2) motivated and talented technicians to join our team. The position involves advanced analyses of clinical trial samples and other specimens using cutting-edge cytometry by time-of-flight (CyTOF) technology, multiplexed tissue imaging, and single-cell RNA sequencing.
The HIMC is an innovation-oriented service center equipped with state-of-the-art instruments. We collaborate closely with clinicians and scientists across multiple departments at Columbia University Irving Medical Center in cancer therapy, immunology, transplantation, neuroscience, and other fields.
Key responsibilities include: operation, maintenance, and troubleshooting of advanced cytometry and imaging instruments; preparation of samples and reagents; and assistance in innovative assay development and optimization.
Please send resume and cover letter to Dr. Victor Guo, manager of HIMC, at email@example.com if interested. Thank you!
• Master the operation and maintenance of the CyTOF and Vectra instruments. Hands-on training will be provided by expert personnel; independent operation for regular tasks is expected within 3-6 months.
• Prepare and manage reagents. Perform reagent validation, titration, and QC. Prepare samples and slides for analysis. Maintain a detailed, up-to-date, and accurate record of samples, reagents, and instrument QC.
• Generate appropriate and timely invoices for users.
• Process data and assist with data analysis.
• Assist in the development of innovative assays, methods, and reagents.
• Contribute to building a culture that embraces scientific excellence, integrity, efficiency, teamwork, and continuous learning and improvement.
• Perform other duties as assigned.
• Bachelor’s degree in biological sciences, engineering, physics, chemistry, math, or computer sciences.
• Good organizational skills and problem identification and solving skills.
• Attention to detail and quality.
• Enthusiasm and ability to learn complex new skills.
• Ability to understand and adhere to instructions and detailed SOPs.
• Ability to perform work in a neat, orderly, and accurate manner.
• Ability to keep accurate and up-to-date records.
• A minimum of a 2-year commitment.
Posted February 5, 2020
Flow Cytometry Scientist
Cerba Research (formerly BARC Global Laboratory)
5 Delaware Ave, Lake Success, NY 11042
Flow Scientists are the key scientific points of contact of Cerba Research (formerly BARC Global Laboratory) with its clients for Flow cytometry specialty testing, present in Cerba Research’s network of collaborator (division/subcontracting) laboratories. Scientists are intensively involved in the development of new assays on these platforms and the quality of the clinical sample test results from these assays. In these areas, they are the internal point of contact for scientific matters and education, as well as they are proactive scientific advisers to Cerba Research’s commercial development
Tasks and Responsibilities:
➢ Be the main scientific consultant with clients:
Interact with clients over email, teleconference (TC) and/or face-to-face meetings.
Support the sales team as expert consultant for clients during client visits and/or via TCs
Translate the client’s needs into a comprehensive set of lab testing, tailored to Cerba Research’s division/subcontracting laboratories’ capacities
Provide updates to the client during assay development and validation, e.g. by having regular TC’s to discuss progress.
Provide updates as needed to the client while the validated assay is in production (clinical sample testing).
➢ Be the pivotal point of contact between the client, Cerba Research, and Cerba Research’s division/subcontractor laboratories for the identified technology platform:
In close collaboration with the laboratory, be a driving force in the design, experimental set-up and validation of these assays.
Provide internal support (as to Contracts and Proposals, Project Management, Data Management) for the implementation of these assays.
Author/co-author validation plans, validation reports and working instructions.
Review data prior to release to the client.
Follow up on pending results, on retests/re-analysis and corrective actions.
➢ Be the internal expert for Flow cytometry related topics:
Maintain personal scientific and technical expertise in the selected areas through practice and education. Maintain personal knowledge on the therapeutic areas of assays validated at Cerba Research.
Identify new methodologies and innovative technologies of relevance.
Be an active member of the Scientific Affairs team. Provide scientific training to internal staff and provide scientific material that will be used by the Sales team.
➢ Be a driver for growth:
Internally, identify possible areas of improvement, at all levels, in how we work with partner laboratories, also according to partners’ needs and ensuring best alignment.
Externally, collaborate with the rest of the Scientific Affairs team and other teams to identify and produce scientific and technical material that will be used to build capabilities awareness by our potential sponsors.
Qualifications (Education and Experience)
- PhD degree in Immunology or oncology, or equal by experience.
- Experience in Flow cytometry assay development and validation.
- Experience in using various Flow cytometry analysis software.
- Understanding of Quality Control / Quality Assurance (ISO 15189, CAP/CLIA, GLP etc.).
- Able to translate complex scientific concepts and techniques into understandable language for internal and external customers.
- Proactive team player.
- Able to take decisions alone where needed.
- Flexible in dealing with problems.
- Punctual and having eye for detail.
Location: Cerba Research (formerly BARC Global Laboratory), 5 Delaware Ave, Lake Success, NY 11042
If you are qualified send your CV to
Posted January 20, 2020
Quality Control Technologist (multiple positions)
Talaris Therapeutics, Louisville, KY
Talaris Therapeutics, Inc. (“Talaris”) is developing a breakthrough, one-time cell therapy to enable patients who receive a living donor kidney transplant to no longer require lifelong immunosuppression, without rejecting their donated organ. Achieving durable, drug-free immune tolerance to a donated organ has been referred to as a “Holy Grail” of organ transplant. In a ground-breaking, phase 2 study conducted between 2008 - 2016, our lead therapy, FCR001, enabled 70% of patients to be weaned off all immunosuppression within 12 months of their kidney transplant. No tolerized patient has had to resume immunosuppression. We have followed these patients for an average of almost five years since their transplant, and the longest for over ten years. Our single-dose cell therapy has also shown the potential to induce durable remission of certain types of severe auto-immune diseases, and to benefit other solid organ transplant patients. Talaris has announced a $100M private financing from leading life sciences investors and has initiated a Phase 3 pivotal trial of our therapy in living donor kidney transplant patients. We also expect to initiate two Phase 2 trials of our therapy in additional indications in 2020. Our cell processing facility and most of our operations are based in Louisville, KY, and we also have a corporate office in Boston, MA.
Job Location: Louisville, KY
Job Description: The Quality Control (QC) Technologist position is responsible for day-to-day QC and analytical testing related to the conduct of Phase I, II, and III clinical trials for a novel cell therapy. This includes performing analytical testing under current Good Manufacturing Practices (cGMP) production of a cell therapy product, immunologic monitoring of test samples, research and development. The primary responsibilities of this role focus on manufacturing; secondary responsibilities may include clinical research and development and program organization activities.
Primary Responsibilities: Perform analytical QC tests including flow cytometry, endotoxin, sterility and cell counts, colony-forming unit and other assays related to the potency and quality control of a cell therapy product in accordance with approved Standard Operating Procedures (SOPs) and adhering to the applicable regulations and standards, including cGMP, Good Tissue Practice (GTP), and American Association of Blood Banks (AABB) standards. Support the qualification and validation of QC equipment and analytical test methods.
Secondary Responsibilities: Participate in clinical research and development, with a focus on flow cytometric assays. Conduct data analysis and prepare reports. Participate in activities such as equipment maintenance, inventory management, ordering of supplies, preparation of SOPs and facility monitoring and maintenance. Participate in training professionals in laboratory procedures and approved SOPs. Perform related duties as assigned.
Requirements: B.S. degree in Biology, Immunology or a related field, Medical Technologist degree, with a minimum of 2 years of relevant laboratory experience or M.S. degree. Experience in flow cytometry, clinical diagnostics, cell culturing, cell processing, blood banking, or transfusion service preferred. General understanding of hematology and immunology concepts.
Additional Qualifications: General understanding of the field of cell therapy processing and cryopreservation preferred. Prior knowledge of GMP regulations preferred. Experience in following standard operational protocols for complex or advanced assays preferred. Ability to work effectively in a fast-paced, rapidly changing environment with flexibility and dedication: Position will require some work outside of the standard work day as related to specific clinical trials.
If interested, please apply: mailto:firstname.lastname@example.org