Job Postings

To post a job on our site, please email metroflowsc@gmail.com

Attach the posting as a Word document and be sure to include instructions on how a candidate should apply.

There is no fee for posting, as this is a complimentary service that we provide to the Cytometry community.

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Posted October 27, 2020

Manager, Flow Cytometry Laboratory

Q2 Solutions

Valencia, California

 

Q2 Solutions is a leading clinical trial laboratory services organization with end-to-end laboratory services and secure, enterprise-wide biospecimen and consent management solutions. With a relentless focus on quality and innovation, Q2 Solutions uses its global experience and scientific expertise to transform science and data into actionable medical insights that help customers improve human health.  A joint venture of IQVIA (formerly QuintilesIMS) and Quest Diagnostics, Q2 Solutions combines the best of each parent organization’s clinical trials laboratory services capabilities to fulfill its mission of treating each sample as if a life depends on it.

 

The ideal candidate will have several years experience with Flow and looking for a career progression.

 

Responsibilities

  • Maintain department directory of service and associated global test codes. Support regional cost sheets and price sheets.

  • Maintain strong internal and external relationships, including global site heads.

  • Management, oversight and coordination of the transition of clinical trials tests from development into global operations.

  • Ensure reliable, secure global procedures are developed, maintained and documented for new tests being implemented.

  • Support Scientific Affairs and Sales in the acquisition of new testing.

  • Review and approve quality control reports used to assess the validity of testing procedure, initiate remedial/corrective action where indicated.

  • Review existing department procedures and make appropriate recommendations to global Lab Operations Managers.

  • Assist Scientific Affairs regarding technical requests including technical principles, advice on choice of tests, test development, cost of testing and result interpretation.

  • Provide clear and timely communication lines with Test Development, Scientific Affairs, Project Management, Pharmaceutical sponsors, laboratory operations, and investigators to ensure global services are developed and appropriate with all regulatory and customer requirements.

  • Develop a good understanding of the Q2 Solutions business and build relationships with global scientists and global laboratory operations.

  • Provide oversight to ensure reliable secure global technical and operational procedures are in place and provide support for improvement opportunities globally.

  • Remain aware of scientific and other advances, as the subject matter expert for department development and maintain skills and knowledge appropriate to the post by undertaking training and attending meetings and conferences.

  • Ensure that safety, environmental, company and departmental policies and procedures are disseminated, understood, complied with and documented.

  • Ensure that employees receive appropriate training in working practices in line with local regulatory bodies.

  • Be familiar with the safety, environmental rules and procedures applying to the job and take reasonable care for personal safety and that of other people.

  • Understand and apply the site Safety, Environmental Policy, Safety Management System and relevant legal safety & environmental requirements

 

Knowledge, Skills and Abilities

  • Excellent communication (interpersonal, verbal and written) skills, ability to communicate effectively at all levels.

  • Knowledge of PC applications

  • In depth knowledge of in clinical testing procedures (flow cytometry).

  • In depth knowledge of laboratory testing regulations (GLP, GCP or CLIA).

  • Working knowledge of quality assurance and quality control principles.

  • Ability to work with global teams.

  • Ability to establish and maintain effective working relationships with coworkers, managers and clients.

  • Knowledge of Health/Safety and Environment good practice.

  • Duty to comply with all applicable standards as required by the company.

  • Deep scientific knowledge/experience with the ability to troubleshoot, guide and provide direction/performance management of staff as well as have an understanding of operating budget and impacts to overall P&L.

  • Skilled in extracting data to measure KPI's and drive continuous improvement

  • Strong knowledge of relevant procedures, processes, and regulations; Working knowledge of department systems (i.e. QLIMS, NewLIMS, QNET, LabMatrix).

  • Strong knowledge of lab safety; proficient in Microsoft Office

  • Good written and oral communication skills

  • Strong supervisory and coaching skills

  • High ethical standards

  • Ability to assess and prioritize multiple tasks, projects and demands

 

Required Education and Experience

  • Minimum of a Bachelor's degree in a health sciences field and 7 years laboratory experience, two of which are flow cytometry, minimum 5 years supervisory experience; or equivalent combination of education, training and experience.

  • ASCP, AMT, NCA certification in Medical Technology (MT) or Medical Lab Scientist (MLS) for Bachelor or  Master’s degree. AAB certification is also acceptable.  PhD or M.D. does not require certification Applicable certifications and licenses as required by country, state, and/or other regulatory bodies.

 

Interested  candidates should apply below:  

https://iqvia.wd1.myworkdayjobs.com/IQVIA/job/Valencia-California-United-States-of-America/Manager--Medical-Labs_R1146876 

 

 www.Q2LabSolutions.com

Carla.Hill@q2labsolutions.com 

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Posted October 16, 2020

Senior Research Scientist

ICON

Farmingdale, NY

At ICON, it’s our people that set us apart.

This is an exciting opportunity to work within a fast paced, busy environment for a leading global provider of outsourced development services to the pharmaceutical, biotechnology and medical device industries. The primary role of the Senior Research Scientist is to oversee the scientific aspects of an assay development/validation project. 

 

The role

  • Independently direct development and validation of new flow cytometry assays, new cell-based assays, and novel circulating tumor cell [CTC] assays

  • Exhibit scientific leadership related to the testing of clinical trial samples for CTC, flow cytometry and cell-based assays

  • Independently manage all aspects of R&D assay validations; experiments, data analysis, sponsor updates, interact with IT department, interact with operational lab, interact with PM 

  • Knowledge of basic computer programs

  • Excellent oral and written communication skills

  • Experienced multi-tasker with the ability to work independently with a high degree of quality

  • Proven track record in delivering focused customer service and client satisfaction

  • Experience in managing multiple projects and meeting deadlines

  • Excellent presentation skills

  • Serve as a scientific leader within the department

  • Ability to remain composed and even-keeled in stressful situations, performing effectively in spite of shifting priorities, workload and external pressures

 

What you need

  • Minimum 10 years of experience in cell-culture, cell-based assays, Flow Cytometry

  • PhD in science related field preferred

  • Strong interpersonal and communication skills, good laboratory and organizational skills, including the ability to work independently and efficiently.

  • Ability to multitask, along with an orientation toward teamwork and leadership, and strong creative thinking and problem solving skills.

 

Why join us?

Ongoing development is vital to us, and as a senior research scientist you will have the opportunity to progress your career, with the potential to move into other related areas to enhance your skill set. Our benefits package is competitive, our scope is international and we genuinely care about our people and their success.

ICON is an equal opportunity employer and committed to providing a workplace free of any discrimination or harassment.

EOE race/color/religion/sex/sexual orientation/gender identity/disability/vet/national origin

 

Benefits of Working at ICON :

Other than working with a great team of smart and energetic people, we also offer a very competitive benefits package.  This varies from country to country so a dedicated recruiter will discuss this with you at interview stage.

We care about our people as they are the key to our success. We provide an open and friendly work environment where we empower people and provide them with opportunities to develop their long term career. 

ICON is an equal opportunity employer, including disability/veteran, and committed to providing a workplace free of discrimination and harassment.

 

Interested individuals should forward their CV to:

Thomas W. Mc Closkey, Ph. D.

Director, Global Research and Development

ICON Laboratory Services

thomas.mccloskey@iconplc.com

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Posted October 16, 2020

Research Scientist

ICON

Farmingdale, NY

At ICON, it’s our people that set us apart.

 

This is an exciting opportunity to work within a fast paced, busy environment for a leading global provider of outsourced development services to the pharmaceutical, biotechnology and medical device industries. The primary role of the Research Scientist is to oversee the scientific aspects of an assay development/validation project. 

 

The role

  • Independently direct development and validation of new flow cytometry assays, new cell-based assays, and novel circulating tumor cell [CTC] assays

  • Exhibit scientific leadership related to the testing of clinical trial samples for CTC, flow cytometry and cell-based assays

  • Independently manage all aspects of R&D assay validations; experiments, data analysis, sponsor updates, interact with IT department, interact with operational lab, interact with PM 

  • Knowledge of basic computer programs

  • Excellent oral and written communication skills

  • Experienced multi-tasker with the ability to work independently with a high degree of quality

  • Proven track record in delivering focused customer service and client satisfaction

  • Experience in managing multiple projects and meeting deadlines

  • Excellent presentation skills

  • Serve as a scientific leader within the department

  • Ability to remain composed and even-keeled in stressful situations, performing effectively in spite of shifting priorities, workload and external pressures

What you need

  • Minimum 5 years of experience in cell-culture, cell-based assays, Flow Cytometry

  • Bachlors degree in science related field required, PhD in science related field preferred

  • Strong interpersonal and communication skills, good laboratory and organizational skills, including the ability to work independently and efficiently.

  • Ability to multitask, along with an orientation toward teamwork and leadership, and strong creative thinking and problem solving skills.

Why join us?

 

Ongoing development is vital to us, and as a research scientist you will have the opportunity to progress your career, with the potential to move into other related areas to enhance your skill set. Our benefits package is competitive, our scope is international and we genuinely care about our people and their success.

 

ICON is an equal opportunity employer and committed to providing a workplace free of any discrimination or harassment.

EOE race/color/religion/sex/sexual orientation/gender identity/disability/vet/national origin

 

Benefits of Working at ICON :

 

Other than working with a great team of smart and energetic people, we also offer a very competitive benefits package.  This varies from country to country so a dedicated recruiter will discuss this with you at interview stage.

We care about our people as they are the key to our success. We provide an open and friendly work environment where we empower people and provide them with opportunities to develop their long term career. 

ICON is an equal opportunity employer, including disability/veteran, and committed to providing a workplace free of discrimination and harassment.

 

Interested individuals should forward their CV to:

Thomas W. Mc Closkey, Ph. D.

Director, Global Research and Development

ICON Laboratory Services

thomas.mccloskey@iconplc.com

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Posted October 16, 2020

Head of Flow Cytometry Facility

EMBL

Heidelberg, Germany

 Staff Category: Faculty Staff Contract Duration: 3 years (renewable)

Grading: 7 or 8; depending on qualifications and experience

Closing Date: 04/10/2020

Reference Number: HD01837 

The EMBL at Heidelberg, Germany is searching for a new head of its Flow Cytometry Core Facility. The Facility is run by in total three staff to provides access, training and support to top of the line technology and assays within the field of Flow Cytometry and single-cell analysis The facility is part of the Core Facility Unit, a vibrant and very interactive technology specialist environment fostering cross-facility projects and method development. The facility has a stable user community of about 100 internal and external users reflecting diverse scientific activities at EMBL which spans from developmental biology, cell biology, genome biology into collaborations with partners from the surrounding scientific landscape. 

Your role 

As head of the Flow Cytometry Core Facility, you will manage two experienced team members to support, and further develop the broad activities of the facility. You will interact with other Core Facilities teams, EMBL scientists and industrial partners to plan, acquire and run state of the art equipment and develop user tangled application workflows. You will also maintain and develop in-house and international training courses in flow cytometry and single cell analyses. An active interaction with the international flow cytometry community is also expected. 

 

You have 

As our ideal candidate, you should have a proven track record of handling, applying, training and providing service in modern flow cytometry and cell sorting. Excellent interpersonal and communication skills, the ability of working in a team and an enthusiastic service attitude are essential. 

 

You might also have 

Experience in supporting industrial partners as a support specialist and experimental advisor. Hands on experience in servicing/maintaining modern Flow Cytometry and cell sorting equipment from e.g. BD and Cytek may be an advantage. Additional experience in running and maintaining legacy Beckman Coulter MoFlo-XDP cell sorters and Coherent Sabr/Innova gas lasers is welcome. It would be an advantage to have experience in single cell analyses e.g. with WTA and targeted 10X Genomics and BD Rhapsody assays and instrumentation in parallel with CiteSeq and AbSeq technology. 

 

Why join us 

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organization with a very collegial and family friendly working environment. The remuneration package comprises a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits, as well as financial support for relocation and installation, including your family and the availability of an excellent child care facility on campus. EMBL is committed to internationality, diversity and equality, and as such encourages applications from underrepresented groups. 

 

What else you need to know 

We are Europe’s flagship research laboratory for the life sciences – an intergovernmental organisation performing scientific research in disciplines including molecular biology, physics, chemistry and computer science. We are an international, innovative and interdisciplinary laboratory with more than 1700 employees from more than 80 countries, operating across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge, Hamburg, Grenoble and Rome. Please note that appointments on fixed term contracts can be renewed, depending on circumstances at the time of the review.

 

Please apply online through: www.embl.org/jobs

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Posted September 25, 2020

Flow Cytometry Research Associate

ICON Laboratory Services

Farmingdale, New York

 

The Research and Development Department at ICON Laboratory Services in

Farmingdale, New York, is seeking a detail oriented applicant with flow

cytometry experience to conduct assay development and validation

projects. 

PURPOSE OF THE JOB:

 

Responsible for conducting experiments for development and validation of

Flow Cytometric  assays. 

 

JOB FUNCTIONS/RESPONSIBILITIES:

 

-Perform assay development and research assignments in the lab.

-Collaborate with the R&D team to present publications and marketing material.

-Prepare reagents as needed, maintain quality control records, compile

any required statistical data, and maintain the cleanliness of work areas.

-Responsible for the performance of required manual procedures and

operation of automated instrumentation.

-Write Standard Operating Procedures.

 

QUALIFICATIONS:

 

-Bachelors degree or equivalent in Science related field.

-More than 2 years laboratory experience.

-Experience in a clinical trials laboratory - preferred.

-Experience in Flow Cytometry and/or Immunoassays - preferred.

-Ability to lift 5-10 lbs.

 

NYS Medical Technologist License and/or American Society of Clinical

Pathologists Certification - desirable.

 

ICON is an Equal Opportunity Employer committed to strength in

diversity.

 

Interested individuals should forward their CV to:

Thomas W. Mc Closkey, Ph. D.

Director, Global Research and Development

ICON Laboratory Services

thomas.mccloskey@iconplc.com

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Posted September 1, 2020

Scientific Research Lead

Memorial Sloan Kettering

New York City, New York

 

Job Details

 

We are currently seeking a Scientific Research Lead. The Scientific Research Lead's main responsibility is to assist the Core Head in implementing and maintaining high scientific standards in the Core Facility, by interacting with researchers across a range of scientific disciplines with diverse levels of technical expertise to seek ways to improve their science and find opportunities to collaborate in new flow cytometry developments.

You will:

  • Consult with investigators, technicians, and students to suggest techniques and protocols relevant to the experimental questions and to ensure that experiments are optimally planned

  • Provide technical and scientific support in flow cytometry from experimental troubleshooting to data analysis

  • Assist with interpretation of data, assurance of data validity, and assurance that publications and presentations using data acquired in the core facility are accurate and appropriate

  • Assist and supervise core staff to ensure best experimental practices, as well as keeping the lab abreast of new technologies and flow cytometry applications

  • Assist in Education & Training of researchers and core staff, including development of new material

  • Develop, design, and conduct projects or experiments within the core’s scope. Coordinate data collection and analysis. Review progress and evaluate results

  • Maintain and establish new collaborations with other laboratories and core facilities, which may result in co-authoring publications and co-presenting results with other groups, as well as in national or international meetings

You have:

  • Doctorate with 2-4 years of sound research experience; Solid expertise in Flow Cytometry, including experience with building and implementing multicolor panels, high-parameter analysis, cell sorting, assay development and sample preparation protocol optimization for cell sorting and analysis, and implementation of best practices in Flow Cytometry.

  • Good publication track using Flow Cytometry

  • Prior experience in Cancer Biology and/or Proteogenomics preferred.

 

Link to apply here

 

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Posted July 21, 2020

Scientist, Clinical Cytometry Assay Development and Implementation

Janssen R&D, pharmaceutical company of Johnson & Johnson

Spring House, Pennsylvania

Janssen Research & Development, LLC, a member of Johnson & Johnson's Family of Companies, is recruiting for a Scientist, Clinical Cytometry Assay Development and Implementation, located in Spring House, PA.

 

At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives.  We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found. 

 

Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, cardiovascular and metabolism, and pulmonary hypertension.  Please visit http://www.janssenrnd.com for more information.

 

As a member of the Clinical Cytometry group within the Oncology Translational Research Department, the Scientist will be responsible for delivering high priority fit-for-purpose biomarker assays to support Phase I through Phase III Oncology clinical studies and ensure high-quality clinical data to enable clinical decision making and the advancement of Oncology drug development programs.

 

Principal Responsibilities:

  • Process human specimens (blood, bone marrow, and solid tissues) to single cell suspension for analysis of immune, tumor, and/or stromal cells by cytometric or other biological methods.

  • Analyze samples and data to characterize both primary immune cell populations and cell lines by multiparameter flow cytometry.

  • Troubleshoot issues that may arise during assay development.

  • Guide the assay development and transition of developed methods to internal or external labs for assay validation.

  • Guide the assay validation and delivery of resulting validation report.

  • Monitor data quality of outsourced assays in clinical sample analysis.

  • Record experimental data and results accurately following SOPs and internal document requirement.

  • Collaborate and communicate with internal stakeholders, management, and external service providers to ensure project priorities are being met.


Qualifications

  • A minimum of a Bachelor’s degree in Biology or a related scientific discipline is required.

  • A minimum of 5 years of hands-on experience in flow cytometry clinical assay development and validation within the healthcare industry or an academic setting is required.

  • Experience with multiparameter flow cytometry, including setting up instrument settings, is required.

  • Flow cytometry data analysis experience is required

  • Experience with aseptic technique, cell culture and cell-based assays required.

  • Clinical trial experience is preferred.

  • Experience in multiparameter flow cytometry panel design is preferred.

  • Experience in determining absolute counts of different cell populations in human sample matrixes is preferred.

  • Experience writing validation reports preferred.

  • Experience with CyTOF assay development and sample analysis preferred.

  • Must have excellent verbal and written communication skills.

  • Must have excellent interpersonal skills, with the ability to interact effectively with people, internally and externally.

  • The ability to effectively present scientific data and concepts to in-house research forums and outside professional meetings is required.

  • The ability to collaborate with all levels of management across a matrix environment is required.

 

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer.  All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.


Primary Location
United States-Pennsylvania-Spring House-
Organization
Janssen Research & Development, LLC (6084)
Job Function
R&D
Requisition ID
5359200623

To apply visit here.

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Posted June 17, 2020

Flow Cytometry Specialist-Hematological Malignancies Program 

Weill Cornell Medicine

New York, NY

Location: Upper East Side  

Org Unit: Melnick Lab Manager 

Work Days:  

Exemption Status: Exempt

Position Summary

This role supports flow cytometry-based basic and translational research for the Heme Malignancy Program. The primary responsibilities include operation of florescence activated cell sorting (FACS) and analyzer instruments, maintenance of flow cytometry equipment, quality control procedures, sample and process tracking, working closely with research scientists and assisting in the training of new users. This role independently performs a full range of complex assignments and projects that involve intensive application of knowledge of flow cytometry in the fields of immunology and cancer biology.

Job Responsibilities

  • Calibrates, maintains and conducts quality control procedures of major fluidic and Optical systems of the flow cytometer, including scheduling, troubleshooting maintenance of one 5-laser Aria BSL2 sorter and Cytek Aurora analyzer.

  • Responsible for daily instrument calibration, modifications and adjustment of instrument parameters; identifies control samples, according to experimental requirements.

  • Ensures protocols are clearly understood and sorting is carried out exactly as requested. Maintains close communication with principal investigators during sorting phase of experiments and contacts researchers with any questions or issues.

  • Maintains reagents and supply inventory.

  • Records quality assessment metrics for flow cytometry results. Reports and documents deviations from standard operating protocols.

  • Schedules use of cell sorting and analyzer equipment to ensure maximum availability.

  • Responsible for establishing and maintaining record keeping systems of instrument parameters, computer data backups and instrument usage.

  • Reviews current flow cytometry literature for improved methodologies and quality control procedures.

  • Provides additional technical support and troubleshoots instrument or computer problems as they arise.

 

Education

  • Bachelor's Degree

Experience

A minimum of 2 years experience with experimental design and experimental execution with multi-color flow cytometric technology.

Flow Cytometry Analyzer experience is required (ie 4-5 laser Fortessa or LSR equivalent).

Experience in the operation of multiparameter cell sorters is highly desirable, but not required. Sorter training will be provided.

Knowledge of BD DIVA software and hardware is required.

Knowledge of biology and scientific approach in order to perform the full range of duties related to experimental protocol and the use of the cytometer to design experiments for original research.

Technical knowledge of aerosol containment and biosafety control procedures associated with flow sorting is preferred.

Experience writing laboratory SOPs and technical instructions is preferred.

Skilled in developing new applications for the cell sorter and participation in the design of experiments.

 

Knowledge, Skills and Abilities

  • Excellent written and verbal communications skills, experience communicating with peers and management of a scientific nature.

  • Highly organized and self motivated.

Weill Cornell Medicine is a comprehensive academic medical center that's committed to excellence in patient care, scientific discovery, and the education of future physicians in New York City and around the world. Our doctors and scientists-faculty from Weill Cornell Medical College, Weill Cornell Graduate School of Medical Sciences, and the Weill Cornell Physician Organization-are engaged in world-class clinical care and cutting-edge research that connect patients to the latest treatment innovations and prevention strategies. Located in the heart of the Upper East Side's scientific corridor, Weill Cornell Medicine's powerful network of collaborators extends to its parent university Cornell University; to Qatar, where an international campus offers a U.S. medical degree; and to programs in Tanzania, Haiti, Brazil, Austria and Turkey. Our medical practices serve communities throughout New York City, and our faculty provide comprehensive care at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, NewYork-Presbyterian/Lower Manhattan Hospital, and NewYork-Presbyterian/Queens. At Weill Cornell Medicine, we work together to treat each individual, not just their conditions or illnesses, as we strive to deliver the finest possible care for our patients - the center of everything we do. Weill Cornell Medicine is an Equal Employment Opportunity Employer. Weill Cornell Medicine provides equal employment opportunities to all qualified applicants without regard to race, sex, sexual orientation, gender identity, national origin, color, age, religion, protected veteran or disability status, or genetic information.

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Posted May 5, 2020

 

Principal Scientist Global Product Quality

Bristol-Myers Squibb

Summit, NJ

Can also be based in Seattle WA

 

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

 

Join us and make a difference.  We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

 

 

The Cellular Therapies Development and Operations (CTDO) organization is seeking a Principal Scientist who will be responsible for the quality oversight of Flow Cytometry methods in support of the Cellular Therapy product portfolio.  This position will report into the Global Product Quality group. Successful candidates will have a strong foundation in multi-parameter flow cytometry assays and demonstrated experience working in a cGMP environment. 

 

Responsibilities:

  • Responsible for the stewardship of late-phase flow cytometry methods in the Quality organization.

  • Implement method lifecycle and method maintenance programs to support flow cytometry methods used in the release of cell therapy drug products.

  • Responsible for transfer and validation of methods from Development to Quality Control (QC) laboratories in compliance with global regulatory requirements.

  • Responsible for authoring relevant analytical sections of submissions, responding to health authority questions and representing the QC function during inspections.

  • Function as the flow cytometry technical expert for QC labs during internal QC investigations and as the Quality liaison with contract test labs during QC investigations.

  • Partner with development organizations in the design of development and qualification studies, selection and characterization of reagents, and method optimization initiatives. Represent the QC department on cross-functional project development teams.


Qualifications and Education Requirements

  • BS/MS in a scientific discipline and 10+ years of experience in multi-parameter (>10-color) flow cytometry execution, training, and technical support. Experience in cellular therapies is preferred.

  • Strong scientific background and expertise with multiple flow cytometry platforms from analyzers to cell sorters.

  • Experience in analytical method lifecycle, including method transfer, validation and maintenance. Experience providing training in method execution as well as instrument operation and standardization. Experience with implementing flow cytometry methods in a commercial QC facility is preferred.

  • Experience in cGMP regulations and application within the Quality Control environment. Understanding of FDA, EMA, ICH, USP, and EP guidelines and regulations associated with the quality control of biological products.

  • Must possess effective time management skills, demonstrate initiative, resourcefulness and flexibility to work independently and as part of a team.

  • Strong technical writing experience (SOPs, Method Validation Protocols and Reports) is required.

 

 

Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

 

 

Apply Today:

https://bristolmyerssquibb.wd5.myworkdayjobs.com/BMS/job/Seattle---WA---US/Principal-Scientist--Global-Product-Quality_R1524599-1

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Posted March 14, 2020

Senior Associate Scientist, Oncology Discovery – Immuno-Oncology

Janssen Research & Development, L.L.C

Spring House, Pennsylvania


Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Senior Associate Scientist, Oncology Discovery – Immuno-Oncology, located in Spring House, PA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science.

We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

As a Senior Associate Scientist within Immuno-Oncology, Oncology Discovery responsibilities will include:

• Support Oncology discovery and Translational research by providing flow cytometry expertise.
• Perform daily instrument set-up of up to 20 BD Diva based flow cytometers and 4 BD cell sorters. Monitor all calibration results to ensure optimal performance and maintain appropriate instrument configurations
• Perform all preventative maintenance activities for instruments and computers, including scheduling and maintenance of service contracts, database back-up, quarterly data transfer/sample disposal, collaboration with IT for computer upgrades and maintaining network access and data share accessibility.
• Aid users in troubleshooting to minimize instrument downtime and need for service calls. Resolve common issues as appropriate, communicate any ongoing issues to users and update calendars as required.
• Perform cell sorting services by request for all non-trained employees. Provide instrument set-up and additional troubleshooting for all trained employees.
• Train all new users on flow core rules and regulations
• Stock all fluids, parts, consumables, and frequently used reagents
• Establish and manage user calendars for each instrument.
• Support all groups as needed with advanced assay/panel design, compensation set-up or issues, and flow data analysis using FlowJo and Cytobank
• Maintain detailed and organized experimental records and stay compliant on all relevant internal and external training requirements
• Process tissue (blood, lymph nodes, tumor, prostate, lung, muscle, spleen, and thymus) to single cell suspension for analysis of immune, tumor, and/or stromal cells by Flow cytometry or other biological methods to support IO efforts
• Stain and characterize both primary immune cell populations and cell lines by multiparameter (8-16 colors) flow cytometry
• Remain up-to-date on the latest flow cytometry trends, assays, and reagents to share across the department.
• Recommend additional training/host relevant speakers to individuals or department as needed.
• Develop and present summaries of data and recommendations


Qualifications
• A minimum of a BS Degree with a minimum of four years’ experience or an MS with two years’ working with flow cytometers in industry or an academic setting is required
• Experience with multi-color flow cytometry including compensation is required
• Experience with troubleshooting BD flow cytometer instrument and software issues is required.
• Experience with FACS (cell sorting) is preferred. Ability to travel to attend specific trainings as needed.
• Experience in design and interpretation of cell-based assays/experiments to interrogate questions in Immunology and oncology is preferred
• Experience with receptor density determination is preferred
• Experience with aseptic technique, cell culture and basic immunogenicity assays is preferred
• Experience with in vivo models of tumor biology, tissue processing, and subsequent flow cytometry is preferred
• Excellent communication/collaboration skills are essential including; interfacing with group leaders, lab managers, and upper management to ensure that instruments are in working order and project priorities are being met is required

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.


Primary Location
United States-Pennsylvania-Spring House-
Organization
Janssen Research & Development, LLC (6084)
Job Function
R&D
Requisition ID
9313200221

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Posted March 11, 2020

Technician

Human Immune Monitoring Core (HIMC) at Columbia University

New York City

The Human Immune Monitoring Core (HIMC) at Columbia University in the New York City is seeking two (2) motivated and talented technicians to join our team. The position involves advanced analyses of clinical trial samples and other specimens using cutting-edge cytometry by time-of-flight (CyTOF) technology, multiplexed tissue imaging, and single-cell RNA sequencing.  

The HIMC is an innovation-oriented service center equipped with state-of-the-art instruments. We collaborate closely with clinicians and scientists across multiple departments at Columbia University Irving Medical Center in cancer therapy, immunology, transplantation, neuroscience, and other fields. 

Key responsibilities include: operation, maintenance, and troubleshooting of advanced cytometry and imaging instruments; preparation of samples and reagents; and assistance in innovative assay development and optimization. 

Please send resume and cover letter to Dr. Victor Guo, manager of HIMC, at xg2295@columbia.edu if interested. Thank you!

 

 

Job Responsibilities

• Master the operation and maintenance of the CyTOF and Vectra instruments. Hands-on training will be provided by expert personnel; independent operation for regular tasks is expected within 3-6 months.

• Prepare and manage reagents. Perform reagent validation, titration, and QC. Prepare samples and slides for analysis. Maintain a detailed, up-to-date, and accurate record of samples, reagents, and instrument QC. 

• Generate appropriate and timely invoices for users.

• Process data and assist with data analysis. 

• Assist in the development of innovative assays, methods, and reagents. 

• Contribute to building a culture that embraces scientific excellence, integrity, efficiency, teamwork, and continuous learning and improvement. 

• Perform other duties as assigned. 

 

 

Minimum Qualifications

• Bachelor’s degree in biological sciences, engineering, physics, chemistry, math, or computer sciences. 

• Good organizational skills and problem identification and solving skills. 

• Attention to detail and quality. 

• Enthusiasm and ability to learn complex new skills. 

• Ability to understand and adhere to instructions and detailed SOPs. 

• Ability to perform work in a neat, orderly, and accurate manner. 

• Ability to keep accurate and up-to-date records. 

• A minimum of a 2-year commitment. 

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Posted February 5, 2020

 

Flow Cytometry Scientist

Cerba Research (formerly BARC Global Laboratory)

5 Delaware Ave, Lake Success, NY 11042

Objectives:

Flow Scientists are the key scientific points of contact of Cerba Research (formerly BARC Global Laboratory) with its clients for Flow cytometry specialty testing, present in Cerba Research’s network of collaborator (division/subcontracting) laboratories. Scientists are intensively involved in the development of new assays on these platforms and the quality of the clinical sample test results from these assays. In these areas, they are the internal point of contact for scientific matters and education, as well as they are proactive scientific advisers to Cerba Research’s commercial development 

Tasks and Responsibilities:

➢           Be the main scientific consultant with clients:

Interact with clients over email, teleconference (TC) and/or face-to-face meetings. 
Support the sales team as expert consultant for clients during client visits and/or via TCs 
Translate the client’s needs into a comprehensive set of lab testing, tailored to Cerba Research’s division/subcontracting laboratories’ capacities 
Provide updates to the client during assay development and validation, e.g. by having regular TC’s to discuss progress. 
Provide updates as needed to the client while the validated assay is in production (clinical sample testing). 

➢           Be the pivotal point of contact between the client, Cerba Research, and Cerba Research’s division/subcontractor laboratories for the identified technology                    platform:

In close collaboration with the laboratory, be a driving force in the design, experimental set-up and validation of these assays.   
Provide internal support (as to Contracts and Proposals, Project Management, Data Management) for the implementation of these assays. 
Author/co-author validation plans, validation reports and working instructions. 
Review data prior to release to the client. 
Follow up on pending results, on retests/re-analysis and corrective actions. 

➢           Be the internal expert for Flow cytometry related topics:

Maintain personal scientific and technical expertise in the selected areas through practice and education. Maintain personal knowledge on the therapeutic areas of assays validated at Cerba Research.
Identify new methodologies and innovative technologies of relevance. 
Be an active member of the Scientific Affairs team. Provide scientific training to internal staff and provide scientific material that will be used by the Sales team.

 

➢           Be a driver for growth:

Internally, identify possible areas of improvement, at all levels, in how we work with partner laboratories, also according to partners’ needs and ensuring best alignment. 
Externally, collaborate with the rest of the Scientific Affairs team and other teams to identify and produce scientific and technical material that will be used to build capabilities awareness by our potential sponsors. 

Qualifications (Education and Experience)

-              PhD degree in Immunology or oncology, or equal by experience.

-              Experience in Flow cytometry assay development and validation.

-              Experience in using various Flow cytometry analysis software.

-              Understanding of Quality Control / Quality Assurance (ISO 15189, CAP/CLIA, GLP etc.).

-              Able to translate complex scientific concepts and techniques into understandable language for internal and external customers.

-              Proactive team player.

-              Able to take decisions alone where needed.

-              Customer-oriented.

-              Flexible in dealing with problems.

-              Punctual and having eye for detail.

Location: Cerba Research (formerly BARC Global Laboratory), 5 Delaware Ave, Lake Success, NY 11042 

If you are qualified send your CV to nselliah@cerbaresearch.com

 

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Posted January 20, 2020

Quality Control Technologist (multiple positions)

Talaris Therapeutics, Louisville, KY  

(www.talaristx.com)

Talaris Therapeutics, Inc. (“Talaris”) is developing a breakthrough, one-time cell therapy to enable patients who receive a living donor kidney transplant to no longer require lifelong immunosuppression, without rejecting their donated organ.  Achieving durable, drug-free immune tolerance to a donated organ has been referred to as a “Holy Grail” of organ transplant.  In a ground-breaking, phase 2 study conducted between 2008 - 2016, our lead therapy, FCR001, enabled 70% of patients to be weaned off all immunosuppression within 12 months of their kidney transplant. No tolerized patient has had to resume immunosuppression.  We have followed these patients for an average of almost five years since their transplant, and the longest for over ten years.  Our single-dose cell therapy has also shown the potential to induce durable remission of certain types of severe auto-immune diseases, and to benefit other solid organ transplant patients.  Talaris has announced a $100M private financing from leading life sciences investors and has initiated a Phase 3 pivotal trial of our therapy in living donor kidney transplant patients.  We also expect to initiate two Phase 2 trials of our therapy in additional indications in 2020.  Our cell processing facility and most of our operations are based in Louisville, KY, and we also have a corporate office in Boston, MA.

Job Location: Louisville, KY

Job Description: The Quality Control (QC) Technologist position is responsible for day-to-day QC and analytical testing related to the conduct of Phase I, II, and III clinical trials for a novel cell therapy. This includes performing analytical testing under current Good Manufacturing Practices (cGMP) production of a cell therapy product, immunologic monitoring of test samples, research and development. The primary responsibilities of this role focus on manufacturing; secondary responsibilities may include clinical research and development and program organization activities.

Primary Responsibilities: Perform analytical QC tests including flow cytometry, endotoxin, sterility and cell counts, colony-forming unit and other assays related to the potency and quality control of a cell therapy product in accordance with approved Standard Operating Procedures (SOPs) and adhering to the applicable regulations and standards, including cGMP, Good Tissue Practice (GTP), and American Association of Blood Banks (AABB) standards. Support the qualification and validation of QC equipment and analytical test methods.

Secondary Responsibilities: Participate in clinical research and development, with a focus on flow cytometric assays. Conduct data analysis and prepare reports. Participate in activities such as equipment maintenance, inventory management, ordering of supplies, preparation of SOPs and facility monitoring and maintenance. Participate in training professionals in laboratory procedures and approved SOPs. Perform related duties as assigned.

Requirements: B.S. degree in Biology, Immunology or a related field, Medical Technologist degree, with a minimum of 2 years of relevant laboratory experience or M.S. degree. Experience in flow cytometry, clinical diagnostics, cell culturing, cell processing, blood banking, or transfusion service preferred. General understanding of hematology and immunology concepts.

Additional Qualifications: General understanding of the field of cell therapy processing and cryopreservation preferred. Prior knowledge of GMP regulations preferred. Experience in following standard operational protocols for complex or advanced assays preferred. Ability to work effectively in a fast-paced, rapidly changing environment with flexibility and dedication: Position will require some work outside of the standard work day as related to specific clinical trials.

If interested, please apply: mailto:careers@talaristx.com